Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

Changes in the stability of microtubules regulate many biological processes, but their role in memory remains unclear. Here we show that learning causes biphasic changes in the microtubule-associated network in the hippocampus. In the early phase, stathmin is dephosphorylated, enhancing its microtub...

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Detalles Bibliográficos
Autores principales: Uchida, Shusaku, Martel, Guillaume, Pavlowsky, Alice, Takizawa, Shuichi, Hevi, Charles, Watanabe, Yoshifumi, Kandel, Eric R., Alarcon, Juan Marcos, Shumyatsky, Gleb P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137320/
https://www.ncbi.nlm.nih.gov/pubmed/25007915
http://dx.doi.org/10.1038/ncomms5389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137320/
https://www.ncbi.nlm.nih.gov/pubmed/25007915
http://dx.doi.org/10.1038/ncomms5389

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