Development of a novel cellular model of Alzheimer’s disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain

Increased production, oligomerization and aggregation of amyloid-β (Aβ) peptides are hallmark pathologies of Alzheimer’s disease (AD). Expressing familial AD mutations (amyloid precursor protein and/or presenilins mutations), the Aβ-pathologies of AD has been recapitulated in animal models of AD. Ve...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghate, Pankaj S, Sidhar, Himakshi, Carlson, George A, Giri, Ranjit K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137416/
https://www.ncbi.nlm.nih.gov/pubmed/25140287
http://dx.doi.org/10.1186/2193-1801-3-161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137416/
https://www.ncbi.nlm.nih.gov/pubmed/25140287
http://dx.doi.org/10.1186/2193-1801-3-161

Ejemplares similares