Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

[Image: see text] The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is detoxified mainly by aldehyde dehydrogenase (ALDH). We find that the fungicide benomyl potently and rapidly inhibits ALDH and builds up DOPAL in vivo in mouse striatum and in vitro in PC12 cells and human cultured f...

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Detalles Bibliográficos
Autores principales: Casida, John E., Ford, Breanna, Jinsmaa, Yunden, Sullivan, Patti, Cooney, Adele, Goldstein, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137984/
https://www.ncbi.nlm.nih.gov/pubmed/25045800
http://dx.doi.org/10.1021/tx5002223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137984/
https://www.ncbi.nlm.nih.gov/pubmed/25045800
http://dx.doi.org/10.1021/tx5002223

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