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Ethynylflavones, Highly Potent, and Selective Inhibitors of Cytochrome P450 1A1
[Image: see text] The flavone backbone is a well-known pharmacophore present in a number of substrates and inhibitors of various P450 enzymes. In order to find highly potent and novel P450 family I enzyme inhibitors, an acetylene group was incorporated into six different positions of flavone. The in...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137986/ https://www.ncbi.nlm.nih.gov/pubmed/25033111 http://dx.doi.org/10.1021/tx5001865 |