Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters

Indoxyl sulfate (IS), a putative low-molecular weight uremic toxin, is excreted in the urine under normal kidney function, but is retained in the circulation and tissues during renal dysfunction in acute kidney injury and chronic kidney disease. IS, which is one of the most potent inducers of oxidat...

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Detalles Bibliográficos
Autores principales: Saigo, Chika, Nomura, Yui, Yamamoto, Yuko, Sagata, Masataka, Matsunaga, Rika, Jono, Hirofumi, Nishi, Kazuhiko, Saito, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137993/
https://www.ncbi.nlm.nih.gov/pubmed/25143712
http://dx.doi.org/10.2147/DDDT.S67456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137993/
https://www.ncbi.nlm.nih.gov/pubmed/25143712
http://dx.doi.org/10.2147/DDDT.S67456

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