Uptake of Compounds That Selectively Kill Multidrug-Resistant Cells: The Copper Transporter SLC31A1 (CTR1) Increases Cellular Accumulation of the Thiosemicarbazone NSC73306

[Image: see text] Acquired drug resistance in cancer continues to be a challenge in cancer therapy, in part due to overexpression of the drug efflux transporter P-glycoprotein (P-gp, MDR1, ABCB1). NSC73306 is a thiosemicarbazone compound that displays greater toxicity against cells expressing functi...

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Detalles Bibliográficos
Autores principales: Fung, King Leung, Tepede, Abisola K., Pluchino, Kristen M., Pouliot, Lynn M., Pixley, Jessica N., Hall, Matthew D., Gottesman, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137994/
https://www.ncbi.nlm.nih.gov/pubmed/24800945
http://dx.doi.org/10.1021/mp500114e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137994/
https://www.ncbi.nlm.nih.gov/pubmed/24800945
http://dx.doi.org/10.1021/mp500114e

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