Comprehensive Analysis of Loops at Protein-Protein Interfaces for Macrocycle Design

Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of chemical biology. Many PPIs have been successfully targeted by mimicking α-helices at interfaces, but most PPIs are mediated by non-helical, non-strand peptide loops. We sought to comprehensively identify a...

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Detalles Bibliográficos
Autores principales: Gavenonis, Jason, Sheneman, Bradley A., Siegert, Timothy R., Eshelman, Matthew R., Kritzer, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138238/
https://www.ncbi.nlm.nih.gov/pubmed/25038791
http://dx.doi.org/10.1038/nchembio.1580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138238/
https://www.ncbi.nlm.nih.gov/pubmed/25038791
http://dx.doi.org/10.1038/nchembio.1580

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