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Comprehensive Analysis of Loops at Protein-Protein Interfaces for Macrocycle Design
Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of chemical biology. Many PPIs have been successfully targeted by mimicking α-helices at interfaces, but most PPIs are mediated by non-helical, non-strand peptide loops. We sought to comprehensively identify a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138238/ https://www.ncbi.nlm.nih.gov/pubmed/25038791 http://dx.doi.org/10.1038/nchembio.1580 |