Probing the shRNA characteristics that hinder Dicer recognition and consequently allow Ago-mediated processing and AgoshRNA activity

Recent evidence indicates the presence of alternative pathways for microRNA (miRNA) and short hairpin (shRNA) processing. Specifically, some of these molecules are refractory to Dicer-mediated processing, which allows alternative processing routes via the Ago2 endonuclease. The resulting RNA molecul...

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Detalles Bibliográficos
Autores principales: Herrera-Carrillo, Elena, Harwig, Alex, Liu, Ying Poi, Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138324/
https://www.ncbi.nlm.nih.gov/pubmed/25035295
http://dx.doi.org/10.1261/rna.043950.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138324/
https://www.ncbi.nlm.nih.gov/pubmed/25035295
http://dx.doi.org/10.1261/rna.043950.113

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