A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity

Leucyl-tRNA synthetases (LeuRSs) catalyze the linkage of leucine with tRNA(Leu). LeuRS contains a catalysis domain (aminoacylation) and a CP1 domain (editing). CP1 is inserted 35 Å from the aminoacylation domain. Aminoacylation and editing require CP1 to swing to the coordinated conformation. The ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Qian, Zhou, Xiao-Long, Hu, Qin-Hua, Lei, Hui-Yan, Fang, Zhi-Peng, Yao, Peng, Wang, En-Duo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138327/
https://www.ncbi.nlm.nih.gov/pubmed/25051973
http://dx.doi.org/10.1261/rna.044404.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138327/
https://www.ncbi.nlm.nih.gov/pubmed/25051973
http://dx.doi.org/10.1261/rna.044404.114

Ejemplares similares