Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways

Reactivation of telomerase in cancers provides an attractive target for developing novel agents to selectively destroy tumor cells. Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me), a synthetic oleanane triterpenoid, inhibited cell proliferation and induced apoptosis in pancreatic canc...

Descripción completa

Detalles Bibliográficos
Autores principales: Deeb, Dorrah, Brigolin, Chris, Gao, Xiaohua, Liu, Yongbo, Pindolia, Kirit R., Gautam, Subhash C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139055/
https://www.ncbi.nlm.nih.gov/pubmed/25152840
http://dx.doi.org/10.4172/2157-2518.1000177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139055/
https://www.ncbi.nlm.nih.gov/pubmed/25152840
http://dx.doi.org/10.4172/2157-2518.1000177

Ejemplares similares