Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling

The Ca(2+) sensor for rapid synaptic vesicle exocytosis, synaptotagmin I (syt), is largely composed of two Ca(2+)-sensing C2-domains, C2A and C2B. We have investigated the apparent synergy between the tandem C2 domains by altering the length and rigidity of the linker that connects them. The behavio...

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Detalles Bibliográficos
Autores principales: Liu, Huisheng, Bai, Hua, Xue, Renhao, Takahashi, Hirohide, Edwardson, J. Michael, Chapman, Edwin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139111/
https://www.ncbi.nlm.nih.gov/pubmed/24657966
http://dx.doi.org/10.1038/nn.3681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139111/
https://www.ncbi.nlm.nih.gov/pubmed/24657966
http://dx.doi.org/10.1038/nn.3681

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