Cargando…
Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling
The Ca(2+) sensor for rapid synaptic vesicle exocytosis, synaptotagmin I (syt), is largely composed of two Ca(2+)-sensing C2-domains, C2A and C2B. We have investigated the apparent synergy between the tandem C2 domains by altering the length and rigidity of the linker that connects them. The behavio...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139111/ https://www.ncbi.nlm.nih.gov/pubmed/24657966 http://dx.doi.org/10.1038/nn.3681 |