Mutational Analysis of the C8-Guanine Adduct of the Environmental Carcinogen 3-Nitrobenzanthrone in Human Cells: Critical Roles of DNA Polymerases η and κ and Rev1 in Error-Prone Translesion Synthesis

[Image: see text] 3-Nitrobenzanthrone (3-NBA), a potent mutagen and suspected human carcinogen, is a common environmental pollutant. The genotoxicity of 3-NBA has been associated with its ability to form DNA adducts, including N-(2′-deoxyguanosin-8-yl)-3-aminobenzanthrone (C8-dG-ABA). To investigate...

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Detalles Bibliográficos
Autores principales: Pande, Paritosh, Malik, Chanchal K., Bose, Arindam, Jasti, Vijay P., Basu, Ashis K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139159/
https://www.ncbi.nlm.nih.gov/pubmed/25080294
http://dx.doi.org/10.1021/bi5007805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139159/
https://www.ncbi.nlm.nih.gov/pubmed/25080294
http://dx.doi.org/10.1021/bi5007805

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