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Paramagnetic Intermediates Generated by Radical S-Adenosylmethionine (SAM) Enzymes
[Image: see text] A [4Fe–4S](+) cluster reduces a bound S-adenosylmethionine (SAM) molecule, cleaving it into methionine and a 5′-deoxyadenosyl radical (5′-dA(•)). This step initiates the varied chemistry catalyzed by each of the so-called radical SAM enzymes. The strongly oxidizing 5′-dA(•) is quen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139163/ https://www.ncbi.nlm.nih.gov/pubmed/24991701 http://dx.doi.org/10.1021/ar400235n |