Omeprazole and Lansoprazole Enantiomers Induce CYP3A4 in Human Hepatocytes and Cell Lines via Glucocorticoid Receptor and Pregnane X Receptor Axis

Benzimidazole drugs lansoprazole and omeprazole are used for treatment of various gastrointestinal pathologies. Both compounds cause drug-drug interactions because they activate aryl hydrocarbon receptor and induce CYP1A genes. In the current paper, we examined the effects of lansoprazole and omepra...

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Detalles Bibliográficos
Autores principales: Novotna, Aneta, Dvorak, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139355/
https://www.ncbi.nlm.nih.gov/pubmed/25141173
http://dx.doi.org/10.1371/journal.pone.0105580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139355/
https://www.ncbi.nlm.nih.gov/pubmed/25141173
http://dx.doi.org/10.1371/journal.pone.0105580

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