The adaptor molecule TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating interleukin-2 receptor signaling

The number of Foxp3(+) regulatory T (T(reg)) cells must be tightly controlled to efficiently suppress autoimmunity while not impairing normal immune responses. Here we show that the adapter molecule TRAF3 is intrinsically required for restraining lineage determination of thymic T(reg) cells. T cell-...

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Detalles Bibliográficos
Autores principales: Yi, Zuoan, Lin, Wai Wai, Stunz, Laura L., Bishop, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139452/
https://www.ncbi.nlm.nih.gov/pubmed/25029551
http://dx.doi.org/10.1038/ni.2944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139452/
https://www.ncbi.nlm.nih.gov/pubmed/25029551
http://dx.doi.org/10.1038/ni.2944

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