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Base Flip in DNA Studied by Molecular Dynamics Simulations of Differently-Oxidized Forms of Methyl-Cytosine

Distortions in the DNA sequence, such as damage or mispairs, are specifically recognized and processed by DNA repair enzymes. Many repair proteins and, in particular, glycosylases flip the target base out of the DNA helix into the enzyme’s active site. Our molecular dynamics simulations of DNA with...

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Detalles Bibliográficos
Autores principales: Helabad, Mahdi Bagherpoor, Kanaan, Natalia, Imhof, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139815/
https://www.ncbi.nlm.nih.gov/pubmed/24995694
http://dx.doi.org/10.3390/ijms150711799