Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

Substantial effort has been placed in developing efficacious recombinant attenuated adenovirus-based vaccines. However induction of immunity to the vector is a significant obstacle to its repeated use. Here we demonstrate that skin-based delivery of an adenovirus-based malaria vaccine, HAdV5-PyMSP1(...

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Detalles Bibliográficos
Autores principales: Carey, John B., Vrdoljak, Anto, O'Mahony, Conor, Hill, Adrian V. S., Draper, Simon J., Moore, Anne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139947/
https://www.ncbi.nlm.nih.gov/pubmed/25142082
http://dx.doi.org/10.1038/srep06154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139947/
https://www.ncbi.nlm.nih.gov/pubmed/25142082
http://dx.doi.org/10.1038/srep06154

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