Enhanced brain delivery of lamotrigine with Pluronic(®) P123-based nanocarrier

BACKGROUND: P-glycoprotein (P-gp) mediated drug efflux across the blood–brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. Howeve...

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Detalles Bibliográficos
Autores principales: Liu, Jian-Sheng, Wang, Jian-Hong, Zhou, Jie, Tang, Xing-Hua, Xu, Lan, Shen, Teng, Wu, Xun-Yi, Hong, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140705/
https://www.ncbi.nlm.nih.gov/pubmed/25152622
http://dx.doi.org/10.2147/IJN.S62263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140705/
https://www.ncbi.nlm.nih.gov/pubmed/25152622
http://dx.doi.org/10.2147/IJN.S62263

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