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Enhanced brain delivery of lamotrigine with Pluronic(®) P123-based nanocarrier

BACKGROUND: P-glycoprotein (P-gp) mediated drug efflux across the blood–brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. Howeve...

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Detalles Bibliográficos
Autores principales:	Liu, Jian-Sheng, Wang, Jian-Hong, Zhou, Jie, Tang, Xing-Hua, Xu, Lan, Shen, Teng, Wu, Xun-Yi, Hong, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140705/ https://www.ncbi.nlm.nih.gov/pubmed/25152622 http://dx.doi.org/10.2147/IJN.S62263

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