RNA Interference Mitigates Motor and Neuropathological Deficits in a Cerebellar Mouse Model of Machado-Joseph Disease

Machado-Joseph disease or Spinocerebellar ataxia type 3 is a progressive fatal neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Recent studies demonstrate that RNA interference is a promising approach for the treatment of Machado-Joseph disease. However, whether gene...

Descripción completa

Detalles Bibliográficos
Autores principales: Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Déglon, Nicole, Pereira de Almeida, Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140724/
https://www.ncbi.nlm.nih.gov/pubmed/25144231
http://dx.doi.org/10.1371/journal.pone.0100086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140724/
https://www.ncbi.nlm.nih.gov/pubmed/25144231
http://dx.doi.org/10.1371/journal.pone.0100086

Ejemplares similares