Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain Displacement

Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a common negative regulatory mechanism that involves intramolecular interactions of the SH3 domain with the PPII helix formed by the SH2-kinase...

Descripción completa

Detalles Bibliográficos
Autores principales: Moroco, Jamie A., Craigo, Jodi K., Iacob, Roxana E., Wales, Thomas E., Engen, John R., Smithgall, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140816/
https://www.ncbi.nlm.nih.gov/pubmed/25144189
http://dx.doi.org/10.1371/journal.pone.0105629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140816/
https://www.ncbi.nlm.nih.gov/pubmed/25144189
http://dx.doi.org/10.1371/journal.pone.0105629

Ejemplares similares