Identification and Biochemical Characterization of an Acid Sphingomyelinase-Like Protein from the Bacterial Plant Pathogen Ralstonia solanacearum that Hydrolyzes ATP to AMP but Not Sphingomyelin to Ceramide

Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine. ASMase deficiency is the underlying cause of the genetic diseases Niemann-Pick Type A and B and has been implicated in the onset and progressio...

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Detalles Bibliográficos
Autores principales: Airola, Michael V., Tumolo, Jessica M., Snider, Justin, Hannun, Yusuf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140839/
https://www.ncbi.nlm.nih.gov/pubmed/25144372
http://dx.doi.org/10.1371/journal.pone.0105830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140839/
https://www.ncbi.nlm.nih.gov/pubmed/25144372
http://dx.doi.org/10.1371/journal.pone.0105830

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