Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia

Most individuals with Friedreich ataxia (FRDA) are homozygous for an expanded GAA triplet repeat (GAA-TR) mutation in intron 1 of the FXN gene, which results in deficiency of FXN transcript. Consistent with the expanded GAA-TR sequence as a cause of variegated gene silencing, evidence for heterochro...

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Detalles Bibliográficos
Autores principales: Chutake, Yogesh K., Costello, Whitney N., Lam, Christina, Bidichandani, Sanjay I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140879/
https://www.ncbi.nlm.nih.gov/pubmed/24737321
http://dx.doi.org/10.1074/jbc.M114.566414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140879/
https://www.ncbi.nlm.nih.gov/pubmed/24737321
http://dx.doi.org/10.1074/jbc.M114.566414

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