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Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil
BACKGROUND: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy. METHODS: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141108/ https://www.ncbi.nlm.nih.gov/pubmed/25117794 http://dx.doi.org/10.1186/1471-2334-14-438 |
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author | Jarduli, Luciana Ribeiro Alves, Hugo Vicentin de Souza-Santana, Fabiana Covolo Marcos, Elaine Valim Camarinha Pereira, Ana Carla Dias-Baptista, Ida Maria Foschiani Fava, Vinícius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila |
author_facet | Jarduli, Luciana Ribeiro Alves, Hugo Vicentin de Souza-Santana, Fabiana Covolo Marcos, Elaine Valim Camarinha Pereira, Ana Carla Dias-Baptista, Ida Maria Foschiani Fava, Vinícius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila |
author_sort | Jarduli, Luciana Ribeiro |
collection | PubMed |
description | BACKGROUND: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy. METHODS: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise multivariate analysis. RESULTS: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form. CONCLUSIONS: This study showed that activating and inhibitory KIR genes may influence the development of leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby demonstrating the role of NK cells in the immunopathology of the disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2334-14-438) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4141108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41411082014-08-23 Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil Jarduli, Luciana Ribeiro Alves, Hugo Vicentin de Souza-Santana, Fabiana Covolo Marcos, Elaine Valim Camarinha Pereira, Ana Carla Dias-Baptista, Ida Maria Foschiani Fava, Vinícius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila BMC Infect Dis Research Article BACKGROUND: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy. METHODS: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise multivariate analysis. RESULTS: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form. CONCLUSIONS: This study showed that activating and inhibitory KIR genes may influence the development of leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby demonstrating the role of NK cells in the immunopathology of the disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2334-14-438) contains supplementary material, which is available to authorized users. BioMed Central 2014-08-12 /pmc/articles/PMC4141108/ /pubmed/25117794 http://dx.doi.org/10.1186/1471-2334-14-438 Text en © Jarduli et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Jarduli, Luciana Ribeiro Alves, Hugo Vicentin de Souza-Santana, Fabiana Covolo Marcos, Elaine Valim Camarinha Pereira, Ana Carla Dias-Baptista, Ida Maria Foschiani Fava, Vinícius Medeiros Mira, Marcelo Távora Moraes, Milton Ozório Virmond, Marcos da Cunha Lopes Visentainer, Jeane Eliete Laguila Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
title | Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
title_full | Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
title_fullStr | Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
title_full_unstemmed | Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
title_short | Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil |
title_sort | influence of kir genes and their hla ligands in the pathogenesis of leprosy in a hyperendemic population of rondonópolis, southern brazil |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141108/ https://www.ncbi.nlm.nih.gov/pubmed/25117794 http://dx.doi.org/10.1186/1471-2334-14-438 |
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