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Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma

Mammalian target of rapamycin (mTOR) is a kinase protein involved in PI3K/AKT signaling with a central role in the processes of cell growth, survival and angiogenesis. Frequent mutations of this pathway make upstream and downstream components novel targets for tailored therapy design. Two mTOR inhib...

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Detalles Bibliográficos
Autores principales:	Kornakiewicz, Anna, Solarek, Wojciech, Bielecka, Zofia F., Lian, Fei, Szczylik, Cezary, Czarnecka, Anna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141323/ https://www.ncbi.nlm.nih.gov/pubmed/25152703 http://dx.doi.org/10.2174/1574362409666140206222746

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