Inhibition of c-Abl Kinase Activity Renders Cancer Cells Highly Sensitive to Mitoxantrone

Although c-Abl has increasingly emerged as a key player in the DNA damage response, its role in this context is far from clear. We studied the effect of inhibition of c-Abl kinase activity by imatinib with chemotherapy drugs and found a striking difference in cell survival after combined mitoxantron...

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Detalles Bibliográficos
Autores principales: Alpay, Kemal, Farshchian, Mehdi, Tuomela, Johanna, Sandholm, Jouko, Aittokallio, Kaappo, Siljamäki, Elina, Kallio, Marko, Kähäri, Veli-Matti, Hietanen, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141754/
https://www.ncbi.nlm.nih.gov/pubmed/25148385
http://dx.doi.org/10.1371/journal.pone.0105526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141754/
https://www.ncbi.nlm.nih.gov/pubmed/25148385
http://dx.doi.org/10.1371/journal.pone.0105526

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