Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis

The proprotein convertase site-1 protease (S1P) converts latent ER-membrane bound transcription factors SREBPs and ATF6 to their active forms. SREBPs are involved in cholesterol and fatty acid homeostasis whereas ATF6 is involved in unfolded protein response pathways (UPR). Cartilage-specific ablati...

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Detalles Bibliográficos
Autores principales: Patra, Debabrata, DeLassus, Elizabeth, Liang, Guosheng, Sandell, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141819/
https://www.ncbi.nlm.nih.gov/pubmed/25147951
http://dx.doi.org/10.1371/journal.pone.0105674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141819/
https://www.ncbi.nlm.nih.gov/pubmed/25147951
http://dx.doi.org/10.1371/journal.pone.0105674

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