An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants

An azide-functionalised analogue of the oxazolidinone antibiotic linezolid was synthesised and shown to retain antimicrobial activity. Using facile ‘click’ chemistry, this versatile intermediate can be further functionalised to explore antimicrobial structure–activity relationships or conjugated to...

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Detalles Bibliográficos
Autores principales: Phetsang, Wanida, Blaskovich, Mark A.T., Butler, Mark S., Huang, Johnny X., Zuegg, Johannes, Mamidyala, Sreeman K., Ramu, Soumya, Kavanagh, Angela M., Cooper, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141890/
https://www.ncbi.nlm.nih.gov/pubmed/25023540
http://dx.doi.org/10.1016/j.bmc.2014.05.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141890/
https://www.ncbi.nlm.nih.gov/pubmed/25023540
http://dx.doi.org/10.1016/j.bmc.2014.05.054

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