Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

INTRODUCTION: Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QT prolongation remains a major cause of attrition during...

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Detalles Bibliográficos
Autores principales: Beattie, Kylie A., Luscombe, Chris, Williams, Geoff, Munoz-Muriedas, Jordi, Gavaghan, David J., Cui, Yi, Mirams, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142193/
https://www.ncbi.nlm.nih.gov/pubmed/23624022
http://dx.doi.org/10.1016/j.vascn.2013.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142193/
https://www.ncbi.nlm.nih.gov/pubmed/23624022
http://dx.doi.org/10.1016/j.vascn.2013.04.004

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