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Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

INTRODUCTION: Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QT prolongation remains a major cause of attrition during...

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Detalles Bibliográficos
Autores principales:	Beattie, Kylie A., Luscombe, Chris, Williams, Geoff, Munoz-Muriedas, Jordi, Gavaghan, David J., Cui, Yi, Mirams, Gary R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142193/ https://www.ncbi.nlm.nih.gov/pubmed/23624022 http://dx.doi.org/10.1016/j.vascn.2013.04.004

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