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Topotecan Monotherapy in Heavily Pretreated Patients with Progressive Advanced Stage Neuroendocrine Carcinomas

Background: Neuroendocrine carcinomas (WHO grade 3) are highly aggressive tumors with an immense tendency to metastasize and with a poor prognosis. In advanced disease, there is no standard treatment beyond first-line platin/etoposide-based chemotherapy. Topotecan is widely used as second-line treat...

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Detalles Bibliográficos
Autores principales: Olsen, Ingrid Holst, Knigge, Ulrich, Federspiel, Birgitte, Hansen, Carsten Palnæs, Skov, Anna, Kjær, Andreas, Langer, Seppo W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142324/
https://www.ncbi.nlm.nih.gov/pubmed/25157273
http://dx.doi.org/10.7150/jca.9409