Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance

Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs. Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptot...

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Detalles Bibliográficos
Autores principales: Su, Jing, Zhou, Lei, Xia, Mei-hui, Xu, Ye, Xiang, Xi-yan, Sun, Lian-kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142381/
https://www.ncbi.nlm.nih.gov/pubmed/25177684
http://dx.doi.org/10.1155/2014/234370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142381/
https://www.ncbi.nlm.nih.gov/pubmed/25177684
http://dx.doi.org/10.1155/2014/234370

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