The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

XMAP215 family members are potent microtubule (MT) polymerases, with mutants displaying reduced MT growth rates and aberrant spindle morphologies. XMAP215 proteins contain arrayed tumor overexpressed gene (TOG) domains that bind tubulin. Whether these TOG domains are architecturally equivalent is un...

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Detalles Bibliográficos
Autores principales: Fox, Jaime C., Howard, Amy E., Currie, Joshua D., Rogers, Stephen L., Slep, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142611/
https://www.ncbi.nlm.nih.gov/pubmed/24966168
http://dx.doi.org/10.1091/mbc.E13-08-0501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142611/
https://www.ncbi.nlm.nih.gov/pubmed/24966168
http://dx.doi.org/10.1091/mbc.E13-08-0501

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