Cargando…
The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array
XMAP215 family members are potent microtubule (MT) polymerases, with mutants displaying reduced MT growth rates and aberrant spindle morphologies. XMAP215 proteins contain arrayed tumor overexpressed gene (TOG) domains that bind tubulin. Whether these TOG domains are architecturally equivalent is un...
Autores principales: | Fox, Jaime C., Howard, Amy E., Currie, Joshua D., Rogers, Stephen L., Slep, Kevin C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142611/ https://www.ncbi.nlm.nih.gov/pubmed/24966168 http://dx.doi.org/10.1091/mbc.E13-08-0501 |
Ejemplares similares
-
Fission yeast Dis1 is an unconventional TOG/XMAP215 that induces microtubule catastrophe to drive chromosome pulling
por: Murase, Yuichi, et al.
Publicado: (2022) -
The TOG protein Stu2/XMAP215 interacts covalently and noncovalently with SUMO
por: Greenlee, Matt, et al.
Publicado: (2018) -
Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast
por: Yukawa, Masashi, et al.
Publicado: (2019) -
Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1
por: Leano, Jonathan B., et al.
Publicado: (2019) -
XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end
por: Farmer, Veronica, et al.
Publicado: (2021)