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A role for nuclear envelope–bridging complexes in homology-directed repair

Unless efficiently and faithfully repaired, DNA double-strand breaks (DSBs) cause genome instability. We implicate a Schizosaccharomyces pombe nuclear envelope–spanning linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of the Sad1/Unc84 protein Sad1 and Klarsicht/Anc1/SYNE1 homology...

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Detalles Bibliográficos
Autores principales: Swartz, Rebecca K., Rodriguez, Elisa C., King, Megan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142617/
https://www.ncbi.nlm.nih.gov/pubmed/24943839
http://dx.doi.org/10.1091/mbc.E13-10-0569