A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome

Reduced levels of brain-derived neurotrophic factor (BDNF) are thought to contribute to the pathophysiology of Rett syndrome (RTT), a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). In Mecp2 mutant mice, BDNF deficits...

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Detalles Bibliográficos
Autores principales: Kron, Miriam, Lang, Min, Adams, Ian T., Sceniak, Michael, Longo, Frank, Katz, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142725/
https://www.ncbi.nlm.nih.gov/pubmed/25147297
http://dx.doi.org/10.1242/dmm.016030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142725/
https://www.ncbi.nlm.nih.gov/pubmed/25147297
http://dx.doi.org/10.1242/dmm.016030

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