Deficiency of prion protein induces impaired autophagic flux in neurons

Normal cellular prion protein (PrP(C)) is highly expressed in the central nervous system. The Zürich I Prnp-deficient mouse strain did not show an abnormal phenotype in initial studies, however, in later studies, deficits in exploratory behavior and short- and long-term memory have been revealed. In...

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Detalles Bibliográficos
Autores principales: Shin, Hae-Young, Park, Jeong-Ho, Carp, Richard I., Choi, Eun-Kyoung, Kim, Yong-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142790/
https://www.ncbi.nlm.nih.gov/pubmed/25202268
http://dx.doi.org/10.3389/fnagi.2014.00207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142790/
https://www.ncbi.nlm.nih.gov/pubmed/25202268
http://dx.doi.org/10.3389/fnagi.2014.00207

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