C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.

Detalles Bibliográficos
Autores principales: Rabe, Sebastian, Moschner, Johann, Bantzi, Marina, Heretsch, Philipp, Giannis, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142839/
https://www.ncbi.nlm.nih.gov/pubmed/25161712
http://dx.doi.org/10.3762/bjoc.10.161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142839/
https://www.ncbi.nlm.nih.gov/pubmed/25161712
http://dx.doi.org/10.3762/bjoc.10.161

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