C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog

The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.

Detalles Bibliográficos
Autores principales: Rabe, Sebastian, Moschner, Johann, Bantzi, Marina, Heretsch, Philipp, Giannis, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142839/
https://www.ncbi.nlm.nih.gov/pubmed/25161712
http://dx.doi.org/10.3762/bjoc.10.161
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author Rabe, Sebastian
Moschner, Johann
Bantzi, Marina
Heretsch, Philipp
Giannis, Athanassios
author_facet Rabe, Sebastian
Moschner, Johann
Bantzi, Marina
Heretsch, Philipp
Giannis, Athanassios
author_sort Rabe, Sebastian
collection PubMed
description The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.
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spelling pubmed-41428392014-08-26 C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog Rabe, Sebastian Moschner, Johann Bantzi, Marina Heretsch, Philipp Giannis, Athanassios Beilstein J Org Chem Full Research Paper The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs. Beilstein-Institut 2014-07-09 /pmc/articles/PMC4142839/ /pubmed/25161712 http://dx.doi.org/10.3762/bjoc.10.161 Text en Copyright © 2014, Rabe et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Rabe, Sebastian
Moschner, Johann
Bantzi, Marina
Heretsch, Philipp
Giannis, Athanassios
C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog
title C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog
title_full C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog
title_fullStr C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog
title_full_unstemmed C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog
title_short C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog
title_sort c–h-functionalization logic guides the synthesis of a carbacyclopamine analog
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142839/
https://www.ncbi.nlm.nih.gov/pubmed/25161712
http://dx.doi.org/10.3762/bjoc.10.161
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