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Rational design of cyclopropane-based chiral PHOX ligands for intermolecular asymmetric Heck reaction
A novel class of chiral phosphanyl-oxazoline (PHOX) ligands with a conformationally rigid cyclopropyl backbone was synthesized and tested in the intermolecular asymmetric Heck reaction. Mechanistic modelling and crystallographic studies were used to predict the optimal ligand structure and helped to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143097/ https://www.ncbi.nlm.nih.gov/pubmed/25161709 http://dx.doi.org/10.3762/bjoc.10.158 |