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OptMAVEn – A New Framework for the de novo Design of Antibody Variable Region Models Targeting Specific Antigen Epitopes

Antibody-based therapeutics provides novel and efficacious treatments for a number of diseases. Traditional experimental approaches for designing therapeutic antibodies rely on raising antibodies against a target antigen in an immunized animal or directed evolution of antibodies with low affinity fo...

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Detalles Bibliográficos
Autores principales: Li, Tong, Pantazes, Robert J., Maranas, Costas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143332/
https://www.ncbi.nlm.nih.gov/pubmed/25153121
http://dx.doi.org/10.1371/journal.pone.0105954