Joint analysis of sequence data and single-nucleotide polymorphism data using pedigree information for imputation and recombination inference

We developed a general framework for family-based imputation using single-nucleotide polymorphism data and sequence data distributed by Genetic Analysis Workshop 18. By using PedIBD, we first inferred haplotypes and inheritance patterns of each family from SNP data. Then new variants in unsequenced...

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Detalles Bibliográficos
Autores principales: Song, Sunah, Shields, Robert, Li, Xin, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143700/
https://www.ncbi.nlm.nih.gov/pubmed/25519372
http://dx.doi.org/10.1186/1753-6561-8-S1-S20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143700/
https://www.ncbi.nlm.nih.gov/pubmed/25519372
http://dx.doi.org/10.1186/1753-6561-8-S1-S20

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