On family-based genome-wide association studies with large pedigrees: observations and recommendations

Family based association studies are employed less often than case-control designs in the search for disease-predisposing genes. The optimal statistical genetic approach for complex pedigrees is unclear when evaluating both common and rare variants. We examined the empirical power and type I error r...

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Detalles Bibliográficos
Autores principales: Fardo, David W, Zhang, Xue, Ding, Lili, He, Hua, Kurowski, Brad, Alexander, Eileen S, Mersha, Tesfaye B, Pilipenko, Valentina, Kottyan, Leah, Nandakumar, Kannabiran, Martin, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143718/
https://www.ncbi.nlm.nih.gov/pubmed/25519377
http://dx.doi.org/10.1186/1753-6561-8-S1-S26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143718/
https://www.ncbi.nlm.nih.gov/pubmed/25519377
http://dx.doi.org/10.1186/1753-6561-8-S1-S26

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