Adjusting for population stratification and relatedness with sequencing data

To avoid inflated type I error and reduced power in genetic association studies, it is necessary to adjust properly for population stratification and known/unknown subject relatedness. It would be interesting to compare the performance of a principal component-based approach with a linear mixed mode...

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Detalles Bibliográficos
Autores principales: Zhang, Yiwei, Pan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143729/
https://www.ncbi.nlm.nih.gov/pubmed/25519386
http://dx.doi.org/10.1186/1753-6561-8-S1-S42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143729/
https://www.ncbi.nlm.nih.gov/pubmed/25519386
http://dx.doi.org/10.1186/1753-6561-8-S1-S42

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