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Adjusting for population stratification and relatedness with sequencing data
To avoid inflated type I error and reduced power in genetic association studies, it is necessary to adjust properly for population stratification and known/unknown subject relatedness. It would be interesting to compare the performance of a principal component-based approach with a linear mixed mode...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143729/ https://www.ncbi.nlm.nih.gov/pubmed/25519386 http://dx.doi.org/10.1186/1753-6561-8-S1-S42 |