A 2-step penalized regression method for family-based next-generation sequencing association studies

Large-scale genetic studies are often composed of related participants, and utilizing familial relationships can be cumbersome and computationally challenging. We present an approach to efficiently handle sequencing data from complex pedigrees that incorporates information from rare variants as well...

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Detalles Bibliográficos
Autores principales: Ding, Xiuhua, Su, Shaoyong, Nandakumar, Kannabiran, Wang, Xiaoling, Fardo, David W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143756/
https://www.ncbi.nlm.nih.gov/pubmed/25519315
http://dx.doi.org/10.1186/1753-6561-8-S1-S25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143756/
https://www.ncbi.nlm.nih.gov/pubmed/25519315
http://dx.doi.org/10.1186/1753-6561-8-S1-S25

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