The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. H...

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Detalles Bibliográficos
Autores principales: Patel, Kashyap, Foretz, Marc, Marion, Allison, Campbell, David G., Gourlay, Robert, Boudaba, Nadia, Tournier, Emilie, Titchenell, Paul, Peggie, Mark, Deak, Maria, Wan, Min, Kaestner, Klaus H., Göransson, Olga, Viollet, Benoit, Gray, Nathanael S., Birnbaum, Morris J., Sutherland, Calum, Sakamoto, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143937/
https://www.ncbi.nlm.nih.gov/pubmed/25088745
http://dx.doi.org/10.1038/ncomms5535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143937/
https://www.ncbi.nlm.nih.gov/pubmed/25088745
http://dx.doi.org/10.1038/ncomms5535

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