Cargando…

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Kashyap, Foretz, Marc, Marion, Allison, Campbell, David G., Gourlay, Robert, Boudaba, Nadia, Tournier, Emilie, Titchenell, Paul, Peggie, Mark, Deak, Maria, Wan, Min, Kaestner, Klaus H., Göransson, Olga, Viollet, Benoit, Gray, Nathanael S., Birnbaum, Morris J., Sutherland, Calum, Sakamoto, Kei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143937/ https://www.ncbi.nlm.nih.gov/pubmed/25088745 http://dx.doi.org/10.1038/ncomms5535

Ejemplares similares

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
por: Boudaba, Nadia, et al.
Publicado: (2018)

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
por: Collodet, Caterina, et al.
Publicado: (2019)

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
por: Cameron, Amy R., et al.
Publicado: (2016)

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes
por: Henriksson, Emma, et al.
Publicado: (2012)

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated
por: Zhou, Wei, et al.
Publicado: (2014)

The Tumor Suppressor Kinase LKB1: Metabolic Nexus
por: Bourouh, Mohammed, et al.
Publicado: (2022)

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
por: Zeqiraj, Elton, et al.
Publicado: (2009)

Tungstate Reduces the Expression of Gluconeogenic Enzymes in STZ Rats
por: Nocito, Laura, et al.
Publicado: (2012)

Developmental regulation of key gluconeogenic molecules in nonhuman primates
por: McGill‐Vargas, Lisa L., et al.
Publicado: (2014)

The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues
por: Nakada, Yuji, et al.
Publicado: (2013)

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
por: Banerjee, Sourav, et al.
Publicado: (2013)

Investigation of LKB1 Ser(431) phosphorylation and Cys(433) farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
por: Houde, Vanessa P., et al.
Publicado: (2014)

Gluconeogenic Signals Regulate Iron Homeostasis via Hepcidin in Mice
por: Vecchi, Chiara, et al.
Publicado: (2014)

Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State
por: Ragavan, Mukundan, et al.
Publicado: (2021)

Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP
por: Miller, Russell A., et al.
Publicado: (2013)

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol
por: Foretz, Marc, et al.
Publicado: (2018)

56371 The Signaling Axis of Tumor Suppressor LKB1 in Triple Negative Breast Cancer
por: Nguyen, Khoa, et al.
Publicado: (2021)

Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation
por: Pan, Dongning, et al.
Publicado: (2013)

Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans
por: Jin, Eunsook S., et al.
Publicado: (2018)

LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
por: Tang, Hei-Man Vincent, et al.
Publicado: (2013)

Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in
por: van der Velden, Yme U., et al.
Publicado: (2011)

The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress
por: Mans, Laurie A., et al.
Publicado: (2017)

Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast
por: Zampar, Guillermo G, et al.
Publicado: (2013)

Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment
por: Eastmond, Peter J., et al.
Publicado: (2015)

glpx Gene in Mycobacterium tuberculosis Is Required for In Vitro Gluconeogenic Growth and In Vivo Survival
por: Gutka, Hiten J., et al.
Publicado: (2015)

The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression
por: Tateya, Sanshiro, et al.
Publicado: (2019)

FOXN3 controls liver glucose metabolism by regulating gluconeogenic substrate selection
por: Karanth, Santhosh, et al.
Publicado: (2019)

Clinical Significance of Plasma Levels of Gluconeogenic Amino Acids in Esophageal Cancer Patients
por: Taherizadeh, Mahsa, et al.
Publicado: (2020)

Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling
por: He, Ling
Publicado: (2021)

Histidine Promotes the Glucose Synthesis through Activation of the Gluconeogenic Pathway in Bovine Hepatocytes
por: Yang, Tianyu, et al.
Publicado: (2021)

OR18-04 Leptin Decreases Gluconeogenesis And Gluconeogenic Substrate Availability In Patients With Lipodystrophy
por: Quaye, Emmanuel, et al.
Publicado: (2023)

Circadian disruption decreases gluconeogenic flux in late-gestation, nonlactating dairy cows
por: Beckett, Linda M., et al.
Publicado: (2023)

Point-of-care testing of HbA1c levels in community settings for people with established diabetes or people at risk of developing type 2 diabetes: a systematic review and meta-analysis protocol
por: Gourlay, Anna, et al.
Publicado: (2023)

Metformin: update on mechanisms of action and repurposing potential
por: Foretz, Marc, et al.
Publicado: (2023)

Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
por: Just, Pierre-Alexandre, et al.
Publicado: (2020)

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation
por: Kyriakis, John M
Publicado: (2003)

The LKB1 Tumor Suppressor Controls Spindle Orientation and Localization of Activated AMPK in Mitotic Epithelial Cells
por: Wei, Chongjuan, et al.
Publicado: (2012)

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis
por: Seong, Chang-Soo, et al.
Publicado: (2023)

LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis
por: Rho, Seung Bae, et al.
Publicado: (2023)

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo
por: Foretz, Marc, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_g6j0lnrq2kilv04j2iv71gmelf